Research interests
Post-transcriptional gene expression regulation
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.
Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J. RNA, 2016. link
PNPT1 release from mitochondria during apoptosis triggers decay of poly(A) RNAs.
Liu X*, Fu R*, Pan Y, Meza-Sosa K, Zhang Z, Lieberman J. Cell, 2018. link
RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells.
Fu R*, Wellman K*, Baldwin A, Rege J, Walters K, Hirsekorn A, Riemondy K, Rainey W, Mukherjee N. RNA, 2021. link
Dynamic RNA Regulation in the Brain Underlies Physiological Plasticity in a Hibernating Mammal.
Fu R*, Gillen A*, Grabek K, Riemondy K, Epperson E, Bustamant C, Hesselberth J, Martin S. Frontiers in Physiology, 2021. link
Liver transcriptome dynamics during hibernation are shaped by a shifting balance between transcription and RNA stability.
Gillen A*, Fu R*, Riemondy K*, Jager J, Fang B, Lazar M, Martin S. Frontiers in Physiology, 2021. link
Transcriptomic Response Dynamics of Human Primary and Immortalized Adrenocortical Cells to Steroidogenic Stimuli.
Wellman K*, Fu R*, Baldwin A, Rege J, Murphy E, Rainey W, Mukherjee N. Cells, 2021. link
Single cell RNA sequencing analysis and software development
In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland.
Fu R, Walters K, Kaufman M, Koc K, Baldwin A, Clay M, Basham K, Kiseljak-Vassiliades K, Fishbein L, Mukherjee N. Journal of the Endocrine Society, 2023. link
Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma.
Fu R, Norris G, Willard N, Griesinger A, Riemondy K, Amani V, Grimaldo E, Harris F, Gilani A, Hankinson T, Mitra S, Hesselberth J, Ritzmann T, Grundy R, Foreman N, Donson A. Neuro-Oncology, 2022. link
clustifyr: an R package for automated single-cell RNA sequencing cluster classification.
Fu R, Gillen A, Sheridan R, Tian C, Daya M, Hao Y, Hesselberth J, Riemondy K. F1000Research, 2020. link
Cell-level metadata are indispensable for documenting single-cell sequencing datasets.
Puntambekar S, Hesselberth J, Riemondy K*, Fu R*. PLoS Biology, 2021. link
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients.
Pei S, Pollyea D, Gustafson A, Stevens B, Minhajuddin M, Fu R, Riemondy K, Gillen A, Sheridan R, Kim J, Costello J, Amaya M, Inguva A, Winters A, Ye H, Krug A, Jones C, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers J, Ashton J, Nemkov T, D’Alessandro A, Gutman J, Fesik S, Ramsey H, Savona M, Smith C, Jordan C. Cancer Discovery, 2019. link
Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node.
Walsh S, Sheridan R, Doan T, Lucas E, Ware B, Fu R, Burchill M, Hesselberth J, Tamburini B. eLife, 2021. link
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